Novel chitosan-acetyl isatin polymer derivatives: synthesis, characterization, and applications in bone tissue engineering
نویسندگان
چکیده
Abstract Novel crystalline and thermally stable chitosan-N-acetylisatin (Chs-NAI) polymer derivatives were synthesized by chitosan modification. These polymers formed insertion of β-cyclodextrin (βCD) doping with zinc oxide nanoparticles (ZnO NPs) yielding pseudopolyrotaxane (Chs-NAI/βCD), Chs-NAI/ZnO-NPs, Chs-NAI/βCD/ZnO NP composites. The chemical structure morphology the newly prepared investigated FTIR, XRD, SEM analyses. Also, optical properties thermal stability analysis examined. results showed that use β-CD or ZnO NPs to modify dramatically improves polymer. weight losses are 66%, 56%, 48%, 59% in Chs-NAI, Chs-NAI/βCD, Chs-NAI/ZnO, Chs-NAI/βCD/ZnO, respectively. For mineral deposition, was presoaked a PO4 3− containing solution before being immersed Ca 2+ solution. nanoparticles/calcium phosphate materials examined confirm deposition calcium on surface using different techniques. Based tests Vero cell lines, NPs)/calcium demonstrated very mild cytotoxicity. In addition, feasibility wide variety hybrid assessed an MTT test, it determined they noncytotoxic under concentrations.
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ژورنال
عنوان ژورنال: Biomass Conversion and Biorefinery
سال: 2022
ISSN: ['2190-6823', '2190-6815']
DOI: https://doi.org/10.1007/s13399-022-03176-8